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When hearts are stressed by disease, energy substrates, called purines, wash out of the cell and the total pool of cellular energy becomes severely depleted

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Binds to GHRH receptors on pituitary somatotroph cells, signaling them to synthesize and release growth hormone into circulation

Nrf2 knockdown prevents NFT-dependent increase in cellular glutathione levels To examine the correlation between Nrf2 activation and the increase in glutathione levels after NFT treatment, Nrf2 protein levels were experimentally lowered by siRNA-mediated knockdown, which was confirmed by Western blotting (Fig