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Exposure to temperatures outside this range, even for short periods, can degrade the medication, rendering it less effective or even unsafe for use
Oral semaglutide was superior to placebo, sitagliptin, and liraglutide and similar to empagliflozin, with losses up to 4.44 kg compared with 0.53.6 kg for active-comparator arms and 0.41.4 kg compared with placebo [35,36,37,38,39,40]
These are peptides, and their amino acid chains denature when exposed to temperatures above roughly 30 degrees Celsius, or 86 degrees Fahrenheit
D., Wang, Z
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