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Later in life patients experience hypokalemia, hypomagnesemia, metabolic alkalosis as well as elevated circulating levels of renin and aldosterone

doi: 10.1046/J.1365-2222.1998.00270.X 135 KangBHChenSSJouLSWengPKWangHW

Patients often seek them out for skin, hair, and nail benefits

User experiences vary dramatically with some reporting maintained benefits months after stopping while others notice gradual decline toward pre-treatment baseline, creating confusion about optimal usage patterns including continuous application versus cycling protocols

The length of effect depends on the dose, how often it is used, and your body's own metabolism