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Consistently, genetically predicted acetyl-carnitine was also related to higher risk of CAD (OR 1.06, 95% CI 1.01 to 1.10) and heart failure (OR 1.07, 95% CI 1.01 to 1.14) (Additional file 2: Fig

The same LASSS treatment also conferred nitration resistance with a greater effect for Y198 than Y250, indicating a novel mechanism independent of an anti-oxidative function of LASSS

Symptoms of PAD can include a persistent cold sensation, leg pain with walking (claudication), slowed healing of cuts, and changes in skin color or hair growth

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