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GLP-1 medications easily counteract this

However, recent insights suggest that the gut and brain GLP-1 systems operate largely independently with mRNA transcripts for proglucagon (GCG), the precursor peptide for GLP-1, being abundant in the brainstem, particularly within the nucleus tractus solitarius (NTS

Generally, your prescribing doctor will advise you on whether or not it's a good idea, but the chances of significant, serious negative side effects are slim

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