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It dates back to 1905, when Russian researchers Gulewitsch & Krimberg discovered this substance in the muscles of mammals

Patients with electrolyte abnormalities or those experiencing significant gastrointestinal fluid losses also warrant closer monitoring

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expired medication compounds this variability further

Decreased urine output or difficulty urinating, potentially signaling dehydration or kidney dysfunction Dark-colored or concentrated urine , which typically indicates dehydration, especially following gastrointestinal side effects Painful urination, urgency, or burning sensation , suggesting a possible urinary tract infection that may require antibiotics Blood in the urine (hematuria), which requires prompt evaluation regardless of other symptoms Foamy or frothy urine that persists, potentially indicating proteinuria or kidney disease Dehydration is a particular concern with semaglutide due to its gastrointestinal side effects