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Compounded options: Compounded Semaglutide Injections (starting at $299/month) Compounded Tirzepatide Injections (starting at $399/month) GLP-1 Liquid Drops GLP-1 Lozenges Oral Semaglutide Liposomal Tablets FDA-approved options: Wegovy Pen (once-weekly injection, starting at $199/month through Shed) Wegovy Pill / Foundayo (once-daily oral tablet, starting at $149/month) Zepbound (via LillyDirect after provider approval) The needle-free formats, including drops, lozenges, and oral tablets, are particularly relevant for people who find injections to be a significant barrier

Short-term treatment with liraglutide positively impacts the microbiome, while prolonged dulaglutide treatment leads to gradual changes in the microbial community, mirroring the slow and steady progress in glycemic control, weight loss, and reduction of inflammation [99,100]