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This landmark direct-comparison trial confirmed that tirzepatide produced approximately 47% greater body weight reduction than semaglutide in adults with obesity over a comparable treatment period the first robust head-to-head evidence in patients without type 2 diabetes

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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve glycemic control by increasing glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and inducing weight loss