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In their respective Phase 3 obesity trials tirzepatide reached roughly 2022.5% and semaglutide 2.4 mg about 14.9%, compared with retatrutides 28.3% at 12 mg though these are separate trials and not head-to-head

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If you reach 8 mg and the side effects are making daily life difficult, dropping back to 4 mg and reassessing is not failure

Peer review Peer review information Nature Medicine thanks Neda Rajamand Ekberg, Nathan R