And the chance of progressing to end-stage renal disease [ESKD] for lupus nephritis patients can be as high as 10%-30%
Robert Kushner, who helped bring them to market, breaks down how they actually work, who benefits most, and why they're a long-term commitment rather than a quick fix
doi: 10.1007/s10815-020-01906-3 50 ZhangTHeQXiuHZhangZLiuYChenZet al
You can't go a day without seeing something about a GLP-1, which is the most common reference to them that we've heard
Patients and trial participants should be aware of the following red flag symptoms that require urgent review: Dysphagia (difficulty swallowing) or odynophagia (painful swallowing) Unexplained weight loss beyond that expected from the medication Persistent vomiting or an inability to keep fluids down Haematemesis (vomiting blood) or melaena (black, tarry stools) Severe or worsening chest pain if you experience severe chest pain, particularly with breathlessness, sweating, or pain radiating to the arm or jaw, call 999 immediately , as these may indicate a cardiac emergency rather than a digestive cause Symptoms that persist despite appropriate self-management , or that significantly affect daily life These symptoms may indicate more serious conditions such as oesophagitis, peptic ulceration, or, in rare cases, upper GI pathology requiring endoscopic investigation