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This is the central challenge for any patch-based claim
L-Theanine Improves Immunity by Altering TH2/TH1 Cytokine Balance, Brain Neurotransmitters, and Expression of Phospholipase C in Rat Hearts
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For example, integrated metabolomics and transcriptomics analyses have revealed distinct alterations in amino acid metabolism (e.g., glutamic acid, arginine, proline) and lipid metabolism pathways in fish muscle and liver under stress or dietary changes [43]
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