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Gatzemeier U, Pluzanska A, Szczesna A, Kaukel E, Roubec J, De Rosa F, et al

By starting with very low doses and titrating slowly, some practitioners believe patients may achieve metabolic benefits whilst minimising tolerability issues

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Therefore, it is necessary to understand how a variety of intrinsic and extrinsic factors are integrated to create the metabolic flexibility and to reduce the metabolic dependencies dictated by oncogenic signaling