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Department of Medicine, University Medical Centre Mainz, Mainz, Germany, (3)Madrigal Pharmaceuticals, (4)Houston Research Institute, Houston, TX, (5)Sorbonne Universit, Assistance Publique-Hpitaux De Paris, Hpital Piti Salptrire, Institute of Cardiometabolism and Nutrition (ICAN), (6)Pinnacle Clinical Research Center, San Antonio, TX Background: MAESTRO-NASH (NCT03900429) is an ongoing 54-month, randomized, double-blind, placebo-controlled Phase 3 trial evaluating the efficacy of resmetirom in patients with biopsy-confirmed nonalcoholic steatohepatitis (NASH) and fibrosis

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Furthermore, UDCA inhibits hypoxia-inducible factor hyperactivation, stabilizing calcium dynamics and preventing hypoxia-induced signaling dysfunction (Mohamed et al., 2017)

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