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Overall, across the two repeat experiments for Cagri and CagriBB bound to the CTR, the conformational equilibrium between the bypass vs CT-like state was similar, suggesting that the salt bridge/ionic lock is sufficient to preferentially stabilize the bypass conformation at CTR (Supplementary Fig
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The study also highlighted AOD9604s influence on fat metabolism and energy expenditure, and its interaction with 3-adrenergic pathways [2]
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