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10.1016/j.jaci.2008.03.035

NNMT-Pathway Interest: 5-Amino-1MQ and related compounds are investigated in obesity and metabolic research models for links to adiposity, methylation balance, and NAD + -associated metabolism

In addition, we found here that inhibition of either the mitochondrial (IDH2) or cytosolic (IDH1 and ME1) NADPH-producing enzymes diminishes ER stress, and we have found previously that inhibition of the pentose phosphate pathway does likewise (Tyra et al., 2012)