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To ensure that this cell death was dependent on caspase-1 activation, we evaluated X(PC) SUP-B15 cell lines with and without doxycycline induction and stained them using the FAM-FLICA caspase-1 reagent

HFpEF and Obesity and Recent or Recurrent Hospitalisation Patients with HFpEF, obesity and a history of recent HF decompensation (within the preceding 12 months) constituted a significant proportion of the populations in the STEP-HFpEF and SUMMIT trials

The gene and protein expression of GLP-1 were upregulated in NTS when activated by chemogenetics

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Early research suggests GLP-1 activation may reduce neuroinflammation and modulate pain perception through multiple biological pathways, potentially offering relief where traditional pain medications have failed