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Under heat stress, sHSPs (such as HSPB1/HSP27) can be phosphorylated and activated via the p38/MAPK-MK2 signaling pathway ( Thus, protein damage and stress sensing represent the initiating phase of the dynamic HSF/HSP response model, determining whether the downstream heat shock response can be promptly activated

Like many other researchers at the time Tschp thought leptin might be a promising candidate for treating obesity

The process takes minutes

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Keep away from direct sunlight & moisture