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Preclinical studies have shown that GLP-1 receptor activation decreases motivation to work for palatable food rewards and reduces consumption of highly rewarding foods
However, researchers who plan on dosing the peptide for longer periods may consider lower doses, such as 10g/kg, because currently the peptide has not been studied clinically for more than 7 days
However, most patients dont come in describing dramatic differences, just subtle shifts
Nature 497 , 249253 (2013)
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