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342 Simultaneously, targeting lactate signaling (e.g., HCAR1 antagonists) may prevent myeloid cell recruitment and immune evasion

Moreover, over time, patients with T2DM have significantly faster progression of motor symptoms, worse depression scores, and are more likely to develop substantial gait impairment and mild cognitive impairment than patients without T2DM [53, 54]

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These findings provided an important basis for further investigating semaglutide as a strategy to reduce dementia risk

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