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Silverstein, P

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Here, we show that replacement of a single amino acid at position 973, just distal to the NPEY motif in the intracellular juxtamembrane region, from leucine, which is highly conserved in IRs, to phenylalanine, the highly conserved homologous residue in IGF1Rs, resulted in decreased IRS-1/PI3K/Akt/mTORC1 signaling and increased Shc/Gab1/MAPK cell cycle signaling

Wissenschaftlicher Hintergrund ist der Schutz der reaktiven SH-Gruppe vor Oxidation, der durch ein spezielles pharmazeutisches Verfahren erzielt wird, das von PD Dr