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Metabolically reprogrammed lactate has been demonstrated to augment GPX4 expression and confer resistance to ferroptosis via activation of the p38-serum glucocorticoid-regulated kinase 1 signaling axis

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These categories reflect a clinical focus on patients with the greatest metabolic and cardiovascular benefit potential, rather than universal weightloss coverage

Cardiovascular, mortality, and kidney outcomes with glp-1 receptor agonists in patients with type 2 diabetes: A systematic review and meta-analysis of randomised trials