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(2) Preparation of compound 4: carrying out acylation coupling reaction on the activated compound 3 and the amino at the end position of Arg34GLP-1 (9-37) in the compound 2 under the action of a condensation reagent and alkali to obtain a compound 4

In STEP 1, participants without diabetes who received semaglutide 2.4 mg weekly lost an average of 14.9% of their body weight over 68 weeks compared to 2.4% with placebo

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