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The inhibition of OCTN2 to reduce the carnitine and LCAC contents has also been shown to be an effective strategy to protect the heart from IRI [298]
doi: 10.1002/hep.20701 14 LebeaupinCValleDHazariYHetzCChevetEBailly-MaitreB
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Oncotarget 9 , 3228032297 (2018)
DNA damage was assessed by immunofluorescence staining for 8-hydroxy-2-deoxyguanosine (8-OHdG), a major product of cell damage resulting from the oxidation of the guanine base in DNA 22
For individuals with Alcohol Use Disorder (AUD) , naltrexone is also commonly used to reduce the pleasurable effects of alcohol and decrease cravings
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