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That extended duration is what makes weekly dosing possible, but it also means the body is exposed to sustained amylin receptor activation far beyond what natural physiology produces

The first factor to be studied extensively was the effect of stress and glucocorticoids on hippocampal neurogenesis and affective states [76]

Heart Health: GLP-1s offer significant cardioprotective effects

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Our team has also shown increased GLP-1 RA prescribing (Gratzl et al., 2024)