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Whereas folate is important to initiate the methylation cycle, B12 is required for the activation of folate from dietary folate to 5-methyltetrahydrofolate, so that it can go on to create the methyl groups SAMe and methionine

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Vitamin B12 deficiency is most common in people who have a disease or condition in which the body is unable to absorb vitamin B12 from ingested foods

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