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Getting enough fluids helps keep digestion moving, which can ease issues like constipation

The CMA also notes that as of late December 2025, Health Canada had nine active applications from companies seeking to sell generic semaglutide

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Your provider will typically recommend a washout period between medications and re-titrate your dose when switching

The study also compared GLP-1 RAs against metformin and found that the peptide treatment correlated with a lower risk of several cancers, though the effect sizes fell short of statistical significance