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Published Phase 2 trial data (NEJM, 2023) demonstrated substantial reductions in body weight in some participants exceeding 20% over approximately 48 weeks making retatrutide one of the most potent agents currently in development for obesity and metabolic disease
10.1186/1740-2557-2-4 99 TaftiD.EhsanM.XixisK
This distinction is not merely academic
For bodybuilders, the interest is practical: intense resistance training places repeated stress on muscles, tendons, joints, and connective tissue
Weight loss results by dose level: what the clinical data shows Numbers matter
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