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Ipamorelin : 2nd-generation GHRP, highly selective for GHS-R1a, no significant impact on cortisol or prolactin the current darling of modern protocols GHRP-6 : first generation, potent but triggers marked hunger (ghrelin-like action on the arcuate nucleus) and slight prolactin/cortisol elevation Hexarelin : most potent on acute GH release, but rapid GHS-R1a desensitization after prolonged use and more pronounced cortisol elevation Key point: GHRPs add an amplifying signal that potentiates GHRH, but chronic monotherapy triggers receptor down-regulation

in this case, two sequential DPP-4-resistant GLP-1 molecules are fused with human albumin (Fig

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Phase 2 obesity data published in The New England Journal of Medicine showed large average weight reductions, which helped establish retatrutide as one of the most closely watched next-generation obesity drugs in development