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PT141 may stimulate the melanocortin system and alter sexual desire or vascular tone

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Results are shown as mean SD, and 1-way ANOVA [ Bdnf mRNA, F (2,6) = 17.990, P = 0.003

This highlights that structurally distinct GLP-1R peptide ligands can exhibit unique HDX signatures, and therefore HDX analysis may be a useful approach for comparing binding mechanisms of peptide ligands