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In the SURPASS-2 clinical trial, Mounjaro demonstrated greater HbA1c reductions compared to semaglutide 1 mg, with mean reductions of up to 2.3% (25 mmol/mol) from baseline at the 15 mg dose
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Results: Retained gastric contents were seen in 18 out of 128 cases in the GLP-1RA users (14.1%), which was statistically significant when compared to 45 out of the 1,156 non-users (3.8%) ( p 50, and patients who were hospitalized
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This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated
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