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The use of the Ca 2+ -sensitive receptor (CaSR) inhibitor NPS-2143 can block the carnitine-induced increase in the cytoplasmic Ca 2+ concentration, indicating that carnitine-induced Ca 2+ mobilization is mediated by the activation of CaSR [119]
doi: 10.1136/annrheumdis-2012-202377 64 GuoY-YWangN-ZZhaoSHouL-XXuY-BZhangN
Wang et al, 2024)
Most patients who combine both report improved metabolic outcomes
However, it is critical to note that no human clinical trials have been published, and the safety and efficacy of 5-Amino-1MQ in humans remain unknown
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