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The interaction between immune components and the gut microbiota is pivotal in the function of the gut-brain-kidney axis, influencing the occurrence and development of other diseases such as inflammatory bowel diseases (IBD), vascular inflammation and cardiovascular diseases, tumors, obesity and metabolic syndrome, nervous system diseases, infectious diseases, and hepatic fibrosis (Wiredu Ocansey et al., 2023)

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Finally, we note that severe oxidative stress causes a "methyl trap" such that the model concentration of 5mTHF more than doubles

4 We will explore this in more detail in later sections

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