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Cited 2/10/17 McCulloch DK (2017): Initial management of blood glucose in adults with type 2 diabetes mellitus

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The GLP-1 receptor agonist component is considered the likely contributor to gastrointestinal side effects, based on established class-effect data from semaglutide and tirzepatide

[63] Research continued, and in 1993, Michael Nauck managed to infuse GLP-1 into people with type 2 diabetes, stimulating insulin while inhibiting glucagon and bringing blood glucose to normal levels