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When interpreted together with the findings of the STEP 4 withdrawal trial and STEP 1 off-treatment extension study, which both showed weight regain after semaglutide discontinuation (after 20 weeks treatment in STEP 4 and 68 weeks treatment in STEP 1) 23,24 , these results support the benefit of continued semaglutide treatment for sustained weight loss
Early detection of serious side effects such as liver toxicity or allergic reactions can be lifesaving
GLP-1 medications can also affect heart rate, and stacking stimulant-based supplements creates unpredictable cardiovascular stress
Medications: Some drugs can interfere with carnitine absorption or increase its excretion
It delivers a more potent GH pulse than a GHRH analog like Sermorelin but without the significant cortisol and prolactin spikes associated with older GHRPs like GHRP-2 or the formidable Hexarelin
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