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Expert Opin Investig Drugs (2011) 20:171722

In addition to safety concerns, the Food and Drug Administration (FDA) criteria for a drug to be approved for treatment of obesity are quite stringent

39 showed 100% sensitivity and specificity for diagnosing OCD lesion instability if the following 3 signs were all present: a high T2 signal intensity rim surrounding a JOCD lesion of the same signal intensity as adjacent joint fluid, a secondary outer rim of low T2 signal intensity, and multiple breaks in the subchondral bone plate

In the SURMOUNT-1 obesity trial, tirzepatide produced mean weight reductions of roughly 1521% depending on dose over 72 weeks ( Jastreboff et al., NEJM 2022

People will need to be obese or overweight and have at least one weight-related health condition to use GLP-1 medications