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In a more recent retrospective study of 1545 patients with WHO-defined PV, conducted by the International Working Group for MPN Research and Treatment (IWG-MRT), thrombosis history at diagnosis was documented in 23% of the patients and included 16% arterial and 7.4% venous events 23
However, there was some evidence that a higher referral rate from general practice may actually be cost-effective owing to improved outcomes associated with earlier diagnosis of melanomas [66]
Clinical approach: Nurses should assess hormonal status, obstetric history, and family history of inherited blood conditions to determine risk and implement preventive strategies
Overall, the trial demonstrated that once-weekly Cagrilintide induced clinically meaningful, dose-dependent weight loss in adults with overweight or obesity, with efficacy comparable or superior to liraglutide 3.0 mg
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