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We were able to single out a protein, Med14, whose activation downstream of GLP-1 helps reprogram pancreatic beta cell gene expression to improve the cells viability and insulin production. Often simply called GLP-1 drugs or GLPs, glucagon-like peptide-1 receptor agonists work by mimicking a hormone our bodies naturally make
The results were a bit better (or worse, depending how you look at it) than he expected
That most anti-cancer drugs are poor substrates for GSTP indicates that the role of elevated GSTP in many tumor cell lines is not to detoxify the compounds, but must have another purpose
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Fatty acid carbon is essential for dNTP synthesis in endothelial cells (vol 520, pg 192, 2015)
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