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doi: 10.1002/ijgo.14538
Furthermore, heme can drive TNF-- and ROS-mediated necroptosis [225], heme oxygenase 1-dependent ferroptosis [226], and NLRP3 inflammasome-associated pyroptosis [227], which are highly proinflammatory RCDs
212,213 In fact, blood levels of active B 6 have been found to decrease in proportion to declining B 2 status, independently of B 6 intake
Consistent with this, pulmonary glutathione levels also display marked circadian variation, suggesting tight circadian control of this antioxidant pathway (59)
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