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How GLP-1 medicines work in the body GLP-1 stands for glucagon-like peptide-1, a natural hormone released in the gut after eating

1 Engs paper, published in the Journal of Biological Chemistry , noted something strange: exendin-4 shared 53% of its amino acid sequence with a human gut hormone called glucagon-like peptide-1 (GLP-1), which had been characterized just a few years earlier

"Lipotropic" means fat-moving: these compounds help keep fat from accumulating in the liver, support bile production, and improve how efficiently stored fat is converted to energy

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Semaglutide has no comparable buffer, so its appetite and gastrointestinal effects rise through the same GLP-1 exposure