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In this regard, orforglipron, an oral, non-peptide, small molecule GLP-1 receptor agonist is a leading compound
Gupta et al., 2012
The primary difference between them is their approved indications and the dosage strengths available
The FDA resolved the semaglutide and tirzepatide shortages in 2025, ending the broad shortage-based pathway that powered large-scale compounding, and in April 2026 proposed excluding these drugs from the 503B bulks list, with a comment period through June 29, 2026
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