More broadly, this reflects a larger issue that obesity is a chronic and complex disease, and we need to do a better job ensuring consistent access to evidence-based therapies
Genetic studies often suffer from small effect sizes, phenotypic heterogeneity, and population stratification, limiting reproducibility across diverse cohorts
de Oliveira B, Oliveira BC, Deutsch G, Pessanha FS, Thire R, de Castilho SR
What it does is remove several of the cushions, the food, the fluids, and the tolerance, that used to blunt the blow
The review further highlights emergent research on "next-generation" therapies with weight-loss efficacy of up to about 24% in clinical trials, approaching weight-loss magnitudes reported in some surgical interventions