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People over 65 or those with lower BMI (27-30 range) may want to consider a more conservative titration schedule, staying at each dose for 6 weeks instead of 4, and possibly targeting 8mg as the maintenance dose rather than pushing to 12mg
For example, some PIs have been shown to alter mitochondrial membrane potential and promote ROS production in hepatocytes and adipocytes
The 3 mg dose is commonly used during treatment initiation to help patients adapt to therapy before dose escalation if clinically appropriate
All four cases of MTC exhibited cytoplasmic GLP-1R expression
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