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5-Amino-1MQ inhibits the enzyme NNMT (nicotinamide N-methyltransferase), which is involved in NAD+ metabolism within fat cells
This mechanism naturally limits absorption when B12 is consumed in large quantities, with excess amounts typically eliminated through the kidneys without causing harm
5-Amino-1MQ Synonyms / Designations: 5-Amino-1-methylquinolinium, 5-Amino-1-MQ, NNMT inhibitor analog CAS Number: 42464-96-0 Molecular Formula: C10H11N2+ (monocationic quaternary ammonium) Molecular Weight: ~159.21 g/mol Purity: 98.5 % (HPLC, typical) Appearance: Off-white to pale yellow crystalline powder Pack Size: 10 mg (total) Storage: Desiccated, protected from light, stored at 20 C Solubility: Soluble in water, dilute acids
Effector molecules including CRISPR/Cas9 RNP and siRNA could be successfully delivered to hard-to-transfect T cells without influencing cell growth or characteristics
