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Researchers believe that increased cAMP levels may activate protein kinase A (PKA), which appears to be a key intracellular signaling molecule
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However, while ephedrine stimulates multiple alpha and beta receptors affecting the cardiovascular system, synephrine only targets beta receptors responsible for fat mobilization, making it a safer alternative by avoiding side effects like tachycardia and hypertension
The genuine unknown is long-term effects in humans
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