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Dehydration at this age requires evaluation by a physician, and IV fluids, if genuinely needed, should be administered in a pediatric urgent care or emergency room setting where appropriate monitoring is available

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In cultured fibroblasts, exposure to the compound at concentrations as low as 10 nM has produced measurable increases in collagen synthesis within 48 hours

Four -ketoacid dehydrogenase complexes ( Figure 4 ), including: (i) the pyruvate dehydrogenase complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A (CoA), an important substrate for energy production via the citric acid cycle

DOI: 10.2337/dc10-1006