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Its dismal prognosis, with a 5-year survival rate below 10%, is largely attributable to late diagnosis, early metastatic dissemination, and profound resistance to conventional chemotherapy and radiotherapy [1]

It typically peaks during dose escalation and subsides as the body adapts to each new dose level

The released lipids are then naturally processed and excreted by the bodys lymphatic system over several weeks

Carnitine octanoyltransferase (CrOT) is predominantly found in peroxisomes and plays a key role in the transfer of medium-chain acyl groups from the peroxisomes to the cytoplasm and mitochondria for further degradation [27]