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2000s: Palatin Technologies modified MT-2's structure to create bremelanotide (PT-141), retaining MC3R/MC4R selectivity for sexual function while reducing MC1R activity (tanning) and improving the pharmacological profile

When used in conjunction with UV exposure, the peptide enhances skin pigmentation, increases eumelanin production, diminishes the presence of sunburn cells, and prolongs the duration of a tan

Tendon and Ligament Healing : Animal research indicates improved structural repair and collagen organization, which relates to recovery from sprains and overuse injuries

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It could sometimes lead to gallstones or kidney problems