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M.MariettiM.HardyT.HenryL.EslamM.et al (2018)
A recent meta-analysis of randomized controlled trials (RCTs), including AMPLITUDE-O, examining six GLP-1 receptor agonists (lixisenatide, liraglutide, subcutaneous semaglutide, exenatide, dulaglutide, and efpeglenatide) reported a 21% reduction in a composite kidney outcome (macroalbuminuria, doubling of serum creatinine or 40% eGFR decline, RRT, or death from kidney disease), corresponding to a number needed to treat of 47 [73]
While tirzepatide shows promise as a treatment for NAFLD, it is essential to adopt a comprehensive approach to liver health management
15 There was no significant adverse effect of exenatide such as hypoglycemia noted in any subject during the cocaine sessions
