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Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) classified as a selective ghrelin/growth hormone secretagogue receptor (GHS-R) agonist
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CagriSema submitted for FDA approval in December 2025 with expected approval in Q4 2026 or Q1 2027, meaning launch around mid-2027
The enzyme -glutamyl transpeptidase (GGT), present in the stomach and intestines, rapidly cleaves the tripeptide back into its constituent amino acids before it can ever reach systemic circulation
The turning point came when I realized I was losing more patients to treatment than to treatment failure
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