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Atherosclerosis: TMAO Activates ERS The ER, formed in continuity with the outer membrane of the nuclear envelope, plays a key role as a central eukaryotic membranous organelle and is responsible for the synthesis, folding, and maturation of membrane and secreted proteins, lipid biosynthesis, and calcium storage (67)

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The mRNA level of PFK , a key glycolysis-related gene, was significantly decreased (fasting state) and increased (feeding state) in the muscle, but was comparable in the liver (Fig

Rigogliuso S, Sabatino MA, Adamo G, Grimaldi N, Dispenza C, Ghersi G